Neuregulin-1 Induces a Negative Inotropic Effect in Cardiac Muscle
نویسندگان
چکیده
منابع مشابه
Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase.
BACKGROUND Deficient cardiac neuregulin/ErbB signaling increases susceptibility to heart failure. In this study, we examined the effects of neuregulin-1 (NRG-1) on myocardial contractility. METHODS AND RESULTS NRG-1 (alpha and beta isoforms) induced a negative inotropic effect in isolated rabbit papillary muscles and a rightward shift of the dose-response curve to isoproterenol. Both effects ...
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We examined the effect of several nitric oxide (NO) donors, authentic NO gas, and L-arginine in isolated cat and rat papillary muscles. We did not observe significant inotropic effects in response to any NO donor (ie, SPM-5185, C87-3754, and S-nitroso-N-acetylpenicillamine [SNAP]) from 1 nmol/L to 100 ,umol/L. Similarly, authentic NO, at concentrations far in excess of those that maximally dila...
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متن کاملPhysiological concentrations of nitric oxide do not elicit an acute negative inotropic effect in unstimulated cardiac muscle.
We examined the effect of several nitric oxide (NO) donors, authentic NO gas, and L-arginine in isolated cat and rat papillary muscles. We did not observe significant inotropic effects in response to any NO donor (ie, SPM-5185, C87-3754, and S-nitroso-N-acetylpenicillamine [SNAP]) from 1 nmol/L to 100 mumol/L. Similarly, authentic NO, at concentrations far in excess of those that maximally dila...
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ژورنال
عنوان ژورنال: Circulation
سال: 2004
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000114521.88547.5e